Enzyme Science (PEA)+
Enzyme Deficiency Patient Assessment Program
Enzyme Deficiency Patient Assessment Program
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Enzyme Deficiency Patient Assessment Program

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  • The Benefits
  • The Science

Support for physiological stress or discomfort associated with occasional stiffness, and compromised tissue function as a result of overexertion and everyday stress.*


In optimal health, the body's natural production of PEA is in homeostasis. This balance can sometimes be compromised due to negative stimuli. As a result, the response to this threat of imbalance can cause a deficiency in PEA production. Supplementation of PEA works with the body to support this delicate balance, calm discomfort, and promote levels for wellbeing.* In combination with Meriva Curcumin, this formula provides natural support for the entire body with a focus on the body's nervous, immune, and muscular systems.*


Enzyme Science offers (PEA)+, a unique blend of PEA, from safflower seed, paired with the well-researched, patented, and highly bioavailable curcumin, Meriva" Phytosome.

There are two sources of PEA commercially available. Synthetic forms require the use of powerful synthetic solvents such as toluene. On the other hand, PEA can be naturally derived from safflower lecithin.
(PEA)+ only utilizes naturally derived palmitoyletha­nolamide from safflower seed.

Recommended Dose: Take 2 capsules twice daily, with or without food. Consult with a physician prior to use if you are pregnant or nursing, taking medications or have a medical condition.

Product Size: (PEA)+ contains 60 and 120 capsules per bottle.

Click the link below to download the spec sheet!


Data collected from the 2012 National Health Interview Survey estimated nearly 56% of American adults (126 million individuals) experienced some level of pain or discomfort within 3 months prior to taking the survey.(1)

Discomfort can range from a variety of indications, including effects on mood, mobility, and overall health and wellness. Most often, occasional pain, stiffness, and compromised tissue are the result of overexertion and everyday stress.

When excited nerves issue sensory information to the brain, the body can react in the form of uncomfortable sensations. Many individuals experiencing common ailments often choose to self-medicate.(2) These consumers turn to easily accessible

Over-the-counter medications such as NSAIDs instead of coping with the short term discomfort. A study, led by the Director of the Slone Epidemiology Center at Boston University, evaluating consumer compliance with recommended NSAID usage, found nearly 20% of individuals exceeded daily maximum doses during a one-week period.(3) When misused or overused, these OTCs can have serious side effects.

For those experiencing only occasional discomforts, a natural approach may be a better option to support physiological stress.* Dietary supplements work with the body's natural processes for physiological stress and soreness without the side effects associated with the overuse of pain medications.*

Palmitoylethanolamide (PEA) is an extensively researched natural ingredient for important neuroprotective actions.*(4) This ingredient has been utilized for decades and is available in dietary supplements worldwide as an option for the onset of physiological stress.*

PEA is an endogenous fatty acid amide that belongs to the family of biologically active lipids that are increased by the body to soothe discomfort naturally.*(5) PEA was identified over 60 years ago when it was isolated from extracts of brain, liver, and muscle of rat and guinea pig. It was later found to be contained in chicken egg yolk, olive oil, safflower and soy lecithin, peanut meal, and several other foods.

1 Nahin RL. J Pain. 2015 Aug;l 6(8):769-80. doi: 10.1016/j.jpain.2015.05.002. Epub 2015 May 29.

2 Sansgiry 55, Bhansali AH, Bapat 55, Xu Q. lntegr Pharm Res Pract. 2016 Dec 19;6:1-6. doi:10.2147/IPRP.5103494. eCollection 2017. Review.

3 Kaufman DW, Kelly JP, Battista DR, Malone MK, Weinstein RB, Shiffman S. Pharmacoepidemiol Drug Saf. 2018 Mar;27(3):322-331. doi: 10.1002/pds.4391. Epub 2018 Jan 26.

4 Scuderi C, Bronzuoli MR, Facchinetti R, et al. Transl Psychiatry. 2018 Jan 31 ;8(1):32. doi: 10.1038/s41398-017-0076-4.

5 Gabrielsson L, Mattsson 5, Fowler CJ. Br J Clin Pharmacol. 2016;82(4):932-42.